| Annotated protein: | Scribble planar cell polarity protein. Gene symbol: SCRIB. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZWS0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SCRIB |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of postsynaptic density membrane (GO:0099147) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Piguel NH, et al. "Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling" Cell Rep. 2014 Oct 23;9(2):712-27 PMID:25310985 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1B-F: "Scribble1 Interacts with the PDZ Binding Domain of the GluN2A and GluN2B Subunits" Fig1. I-K: "The Spatio temporal Localization of Scribble1 Matches that of NMDARs" Using postembedding immunogold electron microscopy, we showed that Scrib1 is localized with NMDARs postsynaptically at excitatory synapses in the stratum radiatum of the CA1 region of the hippocampus (Figures 1I-1K and S1A-S1G; Scrib1: 5 nm gold particles and GluN1: 15 nm gold particles). 11/12/2017 Pim - Based on the interaction with membrane associated proteins NR2A and NR2B, the "extrinsic component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy IP + WB/MSMS Y2H |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 2096 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |