| Annotated protein: | ubiquitinyl hydrolase 1 (EC 3.4.19.12). Gene symbol: USP8. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZN39 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ USP8 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Scudder SL, et al. "Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8" J Neurosci. 2014 Dec 10;34(50):16637-49 PMID:25505317 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4A: "USP8 is present in all fractions and is notably abundant in postsynaptic density fractions (Fig. 4A)" Fig.4B: "We also found that, in a subpopulation of neurons, USP8 was located in punctate clusters and colocalized with the postsynaptic density protein PSD-95 (Fig. 4B), suggesting that it may function at synapses" Moreover, the postsynaptic localization of USP8 is supported by the ubiquitination of postsynaptic AMPARs involved in synaptic transmission. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 2092 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |