| Annotated protein: | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7). Gene symbol: SLC16A7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63344 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC16A7 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) Mossy fiber synapse (DG->CA3) Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Bergersen LH, et al. "Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking" Cereb Cortex. 2005 Apr;15(4):361-70 PMID:15749979 |
| Figure(s): | Fig. 2-6 |
| Annotation description: | The study documents the localization of MCT2 at a variety of glutamatergic synapses using immunogold localization electron microscopy. MCT2 is detected at Schaffer collateral/commissural fibre synapses in CA1, recurrent collateral/commissural fibre synapses in CA3, cerebellar parallel fibre/Purkinje cell synapses (mouse), and to a lesser extent mossy fibre synapses. It is absent from symmetric synapses. 11/12/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Fig. 8 documents the occurrence of MCT2 at synapses between parallel fibers and Purkinjes cell spines next to GluA2/3-containing AMPA receptors and GluR-delta2 containing receptors by immunogold localization in the rat cerebellum. @ PMID:11291733 |
| SynGO annotation ID: | 2086 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |