| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5). Gene symbol: GABRA5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P19969 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA5 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus neocortex |
| Annotated paper: | Serwanski DR, et al. "Synaptic and nonsynaptic localization of GABAA receptors containing the alpha5 subunit in the rat brain" J Comp Neurol. 2006 Nov 20;499(3):458-70 PMID:16998906 |
| Figure(s): | Fig.4, 5 |
| Annotation description: | Fig.4: "Single-label experiments also show anti-α5 immunogold particles that are associated with synapses (arrows, Fig. 4 I-K), frequently having symmetric, or Gray's type 2, morphology (Fig. 4 I and J)." Fig,5: "Double-labeling experiments with the postsynaptic GABAergic markers β2/3 or γ2 GABAAR subunits or gephyrin (Fig. 5 F-Q), showed that the α5 immunoreactivity (arrows, Fig. 5 F-N), was associated with synaptic membranes at GABAergic synapses." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2083 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |