| Annotated protein: | Metabotropic glutamate receptor 5 (mGluR5). Gene symbol: GRM5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q3UVX5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRM5 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Huber KM, et al. "Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1" J Neurophysiol. 2001 Jul;86(1):321-5 PMID:11431513 |
| Figure(s): | fig 2 |
| Annotation description: | This study shows that the chemical induction of a specific form of long-term depression (LTD) using the group I mGluR agonist DHPG (mGluR-LTD) is absent in mGluR5 knockout mice. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 2064 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |