| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1). Gene symbol: GABRA1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62813 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Nusser Z, et al. "Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells" Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11939-44 PMID:8876241 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "GABAA receptors in synaptic junctions on somata" - "Immunopositive synapses (at least two gold particles per synapse; see Materials and Methods) for the al subunit were found on somata (Fig. 1A), proximal (Fig. 1B) and distal dendrites, spines (Fig. 1C)," Abstract: ". The al subunit has been found in most GABAergic synapses on all postsynaptic domains of pyramidal cells. In contrast, the a2 subunit was located only in a subset of synapses on the somata and dendrites, but in most synapses on axon initial segments innervated by axo-axonic cells." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2061 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |