| Annotated protein: | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3). Gene symbol: GABRB3. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63080 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRB3 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | cerebral cortex, GABAergic |
| Annotated paper: | Ramadan E, et al. "GABA(A) receptor beta3 subunit deletion decreases alpha2/3 subunits and IPSC duration" J Neurophysiol. 2003 Jan;89(1):128-34 PMID:12522165 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "Whole cell patch-clamp recordings of synaptic currents in beta3 -/- cortical neurons." - "the weighted time constant resulting from the double-exponential fitting of the mIPSCs decay (Tw) was 2.5-fold larger in the beta3 +/_ than in beta3 -/- neurons (Fig. 3)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2060 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |