| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2). Gene symbol: GABRA2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P26048 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | amygdala, GABAergic |
| Annotated paper: | Geracitano R, et al. "Functional expression of the GABA(A) receptor alpha2 and alpha3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala" Front Neural Circuits. 2012 May 31;6:32 PMID:22666188 |
| Figure(s): | Fig.4 |
| Annotation description: | "Silver-intensified immunogold reaction for the α2 subunit revealed intense labeling of symmetric synapses (Figures 4C,D)." Note: staining is more centered around the postsynapse. No quantification was included. - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2058 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |