| Annotated protein: | Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93). Gene symbol: DLG2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63622 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DLG2 |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of postsynaptic density membrane (GO:0099031) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Sans N, et al. "A developmental change in NMDA receptor-associated proteins at hippocampal synapses" J Neurosci. 2000 Feb 1;20(3):1260-71 PMID:10648730 |
| Figure(s): | Figure 6 |
| Annotation description: | Immunogold labeling demonstrates PSD-93 is concentrated within the postsynaptic density of dendritic spines in CA1 neurons of the adult rat hippocampus (Figure 6). Similar to PSD-95, PSD-93 is anchored to the postsynaptic plasma membrane via palmitoylation and increases in abundance at excitatory synapses with age (Figure 6, P2, P10, P35). Antibodies used in electron microscopy experiments were validated by western blot analysis of rat hippocampus and ectopic expressing in HEK cells (Figure 1, Table 1 - information for all antibodies used). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
| Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| SynGO annotation ID: | 2050 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |