| Annotated protein: | Glycine receptor subunit beta (Glycine receptor 58 kDa subunit). Gene symbol: GLRB. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P20781 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GLRB |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization (GO:0099572) |
| Synapse type(s): | spinal cord, glycinergic |
| Annotated paper: | Weltzien F, et al. "Distribution of the glycine receptor beta-subunit in the mouse CNS as revealed by a novel monoclonal antibody" J Comp Neurol. 2012 Dec 1;520(17):3962-81 PMID:22592841 |
| Figure(s): | Fig.4, 5 |
| Annotation description: | "mAb-GlyRβ revealed immunoreactive puncta along the dendrites and on the somata of SCNs. B-D: Double-labeling with mAb-GlyRβ and a VIAAT antibody revealed significant apposition of GlyRβ puncta to inhibitory nerve terminals. E-G: Additionally, GlyRβ staining colocalized with gephyrin clusters detected by a polyclonal antibody." 18/02/2021 Dnyanada: The high degree of colocalisation of GlyRβ puncta with gephyrin make it suitable for a specific ontology term "postsynaptic specialization" (previously annotated to the term "synapse"). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2038 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |