| Annotated protein: | Glycine receptor subunit alpha-3. Gene symbol: GLRA3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P24524 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GLRA3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | retina, glycinergic |
| Annotated paper: | Haverkamp S, et al. "Glycine Receptor Diversity in the Mammalian Retina" PMID:22574341 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: Postembedding electron microscopy of GlyRα3 on ultrathin sections of mouse retina. The GlyR subunit is localized at the postsynaptic membrane of an amacrine cell synapse (provided by Christian Puller, unpublished data). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Glycine receptors (GlyRs) and their role in retinal circuitry were analyzed immunocytochemically in wild-type and GlyR alpha3 subunit-deficient (Glra3(-/-)) mouse retinae. GlyRs are localized in the inner plexiform layer in brightly fluorescent puncta, which are likely to represent postsynaptically clustered GlyRs. Approximately one third of the clusters were found to contain the alpha1 subunit, and half possessed the alpha3 subunit. @ PMID:12975813 |
| SynGO annotation ID: | 2036 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |