| Annotated protein: | Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit). Gene symbol: GLRA1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P07727 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GLRA1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | pons, glycinergic |
| Annotated paper: | Trojanova J, et al. "Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal" Front Neural Circuits. 2014 Oct 6;8:120 PMID:25339867 |
| Figure(s): | Fig.2 |
| Annotation description: | Background: - This paper investigates inhibitory synapse onto presynaptic terminals on the Calyx of Held. - The investigated GlycR subunit is alpha1. Fig.2C: Electron micrograph showing clusters of GlyR-associated IG particles (arrowheads) at postsynaptic sites juxtaposed with putative inhibitory terminals. Note: although at first sight this may seem to represent presynaptic GlycRs, these GlycRs are part of a postsynaptic element of inhibitory synapses onto the terminal: " Calyceal GlyRs, however, do not preferentially locate near the glutamate release sites in domains typical for analogous presynaptic autoreceptors." The appparent clustering of GlyRs under surrounding boutons strengthens this idea. Annotation to 'integral component of postsynaptic specialization membrane (GO:0099060)' was made. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Fig.1D: PSD localization of alpha1 in the rabbit retina (IPL). @ PMID:9667008 |
| SynGO annotation ID: | 2034 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |