| Annotated protein: | Glycine receptor subunit alpha-2. Gene symbol: GLRA2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q7TNC8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GLRA2 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | retina, glycinergic |
| Annotated paper: | Majumdar S, et al. "Glycinergic input of widefield, displaced amacrine cells of the mouse retina" J Physiol. 2009 Aug 1;587(Pt 15):3831-49 PMID:19528249 |
| Figure(s): | Fig.7 |
| Annotation description: | "Group II cells showed glycinergic sIPSCs and glycine induced currents in wild-type, Glra1spd-ot and Glra3-/- mice (τ~25 ms); however, glycinergic currents were absent in group II cells of Glra2-/- mice ... We propose that GlyRs of group II cells are dominated by the α2 subunit". |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2028 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |