Annotated protein: | Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit). Gene symbol: GLRA1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64018 |
antibody wiki: | |
SynGO gene info: | SynGO data @ GLRA1 |
Ontology domain: | Biological Process |
SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
Synapse type(s): | medulla, glycinergic |
Annotated paper: | Schaefer N, et al. "Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease" J Neurosci. 2017 Aug 16;37(33):7948-7961 PMID:28724750 |
Figure(s): | Fig.6 |
Annotation description: | Shaky mice have spontaneous mutation of the GLRA1 coding sequence. The Shaky GLRA1 has defective trafficking to postsynapses and displays problems with glycinergic (blocked by strychnine in WT animals) postsynaptic responses in PreBötC neurons. |
Evidence tracking, Biological System: | Intact tissue |
Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
Additional literature: | The spasmodic and oscillator mice also have mutations in GLRA1 gene resulting in perturbed glycinergic IPSCs. @ PMID:16672662 |
SynGO annotation ID: | 2027 |
Dataset release (version): | 20231201 |
View annotation as GO-CAM model: |