| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-3. Gene symbol: CHRNA3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P04757 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA3 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | striatum, dopaminergic |
| Annotated paper: | Mogg AJ, et al. "Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum" J Pharmacol Exp Ther. 2002 Jul;302(1):197-204 PMID:12065717 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig. 2: "In the presence of 100 nM α-CTx-MII, a concentration that has been shown to selectively and maximally inhibit α3β2* nAChR (Cartier et al., 1996; Kaiser et al., 1998), [3H]dopamine release evoked by 10 μM nicotine was decreased by 35.5 ± 4.9% (n = 3,p < 0.01; Fig. 2)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) radioisotope assay evidence |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2026 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |