| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-7. Gene symbol: CHRNA7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q05941 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA7 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hippocampus, glycinergic |
| Annotated paper: | Zappettini S, et al. "Different presynaptic nicotinic receptor subtypes modulate in vivo and in vitro the release of glycine in the rat hippocampus" Neurochem Int. 2011 Oct;59(5):729-38 PMID:21762741 |
| Figure(s): | Fig.2, Table I |
| Annotation description: | MLA and PHA-543613 (alpha7 specific agents) modulate the release of glycine from hippocampal synaptosomes. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) radioisotope assay evidence |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2024 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |