| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-5. Gene symbol: CHRNA5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q2MKA5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA5 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | striatum, dopaminergic |
| Annotated paper: | Grady SR, et al. "Mouse striatal dopamine nerve terminals express alpha4alpha5beta2 and two stoichiometric forms of alpha4beta2*-nicotinic acetylcholine receptors" J Mol Neurosci. 2010 Jan;40(1-2):91-5 PMID:19693710 |
| Figure(s): | Fig.2, Table 1 |
| Annotation description: | "Striatal synaptosomes from wild-type and α5 null mutant mice (n=3 each genotype) were assayed for α-CtxMII-resistant (α4β2*-nAChR) DA release by 5 s exposures to ACh (0.1-3,000 μM). The results of the biphasic curve fit indicate that α5 deletion results in a significant decrease in HS maximal release (P<0.05)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) radioisotope assay evidence |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2023 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |