| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-4. Gene symbol: CHRNA4. Taxonomy: Mus musculus (Mouse). Uniprot ID: O70174 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA4 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | striatum, dopaminergic |
| Annotated paper: | Champtiaux N, et al. "Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice" J Neurosci. 2003 Aug 27;23(21):7820-9 PMID:12944511 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "The effect of 3 μm nicotine on DA release was reduced by half in both α4-/- and α6-/- animals (compared with α4+/+ and α6+/+ animals, respectively) and completely abolished in α4-/-α6-/- or β2-/- animals (Fig. 3A)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) radioisotope assay evidence |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2021 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |