| Annotated protein: | Neuronal acetylcholine receptor subunit beta-2. Gene symbol: CHRNB2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9ERK7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNB2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | striatum, dopaminergic |
| Annotated paper: | Grady SR, et al. "Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum" J Neurochem. 2001 Jan;76(1):258-68 PMID:11145999 |
| Figure(s): | Fig.5 |
| Annotation description: | Fig.4: "The deletion of the β2 subunit had no effect on agonist-stimulated acetylcholine release, but abolished agonist-stimulated release of dopamine from striatal synaptosomes" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) radioisotope assay evidence |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2019 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |