| Annotated protein: | Acetylcholine receptor subunit epsilon. Gene symbol: CHRNE. Taxonomy: Mus musculus (Mouse). Uniprot ID: P20782 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNE |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Wang ZZ, et al. "Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice" J Neurosci. 2003 Jun 15;23(12):5161-9 PMID:12832540 |
| Figure(s): | Fig.6 |
| Annotation description: | Localization of the fetal nACHR subunit epsylon to motor endplates (stained with alpha-BTX) is shown with an anti-epsilon anitbody. The localization of the epsilon-containing nACHR under study is without a single doubt in the postsynaptic specialization membrane. - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2016 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |