Annotated protein:	Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10). Gene symbol: CHRNA10. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9JLB5
antibody wiki:	search antibodypedia...
SynGO gene info:	SynGO data @ CHRNA10
Ontology domain:	Cellular Component
SynGO term:	integral component of postsynaptic specialization membrane (GO:0099060)
Synapse type(s):	cochlea, acetylcholinergic
Annotated paper:	Osman AA, et al. "Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear" Mol Cell Neurosci. 2008 Jun;38(2):153-69 PMID:18420419
Figure(s):	Fig.4
Annotation description:	Fig.4 "α-Bungarotoxin (α-Bgtx) labeling of nAChR α9 and α10 in cochlear tissues and cultured cells" At P10 VAChT labeled presynaptic terminals overlap extensively with alpha-Bgtx staining. In cochlear hair cells the alphya-Btx staining is mediated by alpha9/alpha10 heteromeric nAHCRs. Rapsyn, a component of the muscle postsynaptic specialization, binds and mediates aggregation of alpha-Bgtx (=alpha9/alpha10 heteromeric nAHCRs) in non-neuronal cells. This is another indirect indication of localization of alpha9/alpha10 heteromeric nAHCRs to the cholinergic postsynaptic specialization. - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:	Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:	2010
Dataset release (version):	20231201
View annotation as GO-CAM model: