| Annotated protein: | Neuronal acetylcholine receptor subunit beta-3. Gene symbol: CHRNB3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BMN3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNB3 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | striatum, dopaminergic |
| Annotated paper: | Cui C, et al. "The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors" J Neurosci. 2003 Dec 3;23(35):11045-53 PMID:14657161 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6 "β3-containing nAChRs mediate striatal dopamine release" The application of nicotine to striatal synaptosomes stimulates the release of dopamine. This response can be inhibited by nicotinic antogonist α-conotoxin MII. Sensitivity to α-conotoxin MII is reduced in preparations of a beta3 KO mouse. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Biochemical fractionation (generic) radioisotope assay evidence |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2008 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |