| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-3. Gene symbol: CHRNA3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R4G9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | superior cervical ganglion (SCG), acetylcholinergic |
| Annotated paper: | Del Signore A, et al. "Dystrophin stabilizes alpha 3- but not alpha 7-containing nicotinic acetylcholine receptor subtypes at the postsynaptic apparatus in the mouse superior cervical ganglion" Neurobiol Dis. 2002 Jun;10(1):54-66 PMID:12079404 |
| Figure(s): | Fig.2 (not shown) |
| Annotation description: | Literal: "At the cell surface, the immunoreaction product for the four nAChR subunits was found associated with the postsynaptic specializations of several synapses established on the soma and dendrites of the ganglionic neurons. Figures 2C (wild-type) and 2D (mdx) show two postsynaptic apparatus immunopositive for the alpha7 and beta2 subunits, respectively." Note: - With "the four nAChR subunits" the authors mean alpha3, alpha7, beta2 and beta4. - Images of immuno-EM data for alpha3 and beta4 is not included in the paper figures (data not shown) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2000 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |