| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10). Gene symbol: CHRNA10. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9JLB5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA10 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | cochlea, acetylcholinergic |
| Annotated paper: | Elgoyhen AB, et al. "alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells" Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3501-6 PMID:11248107 |
| Figure(s): | Fig.3, Table 1, Fig.4 |
| Annotation description: | Previous data PMID:10875922: synaptic currents that inhibit cochlear hair cells is blocked by alphaBtx and strychnine. alpha9 nACHR subunit is specifically expressed in cochlear hair cells and is specifically targeted by alphaBtx and strychnin in these cells (alpha7 and muscle-type nAChRs that are also sensitive to alphaBtx are not expressed). This paper reports of the identification of the alpha10 subunit. alpha10 is expressed in cochlear hair cells and when co-epxressed in oocytes assebles into functional nACHRs with alpha9. These alpha/9alpha10 receptors have pharmacological properties that more resemble the cochlear nAChRs compared to alpha9 homopentamers. It is therefore generally believed that the cochlear nAChR is an alpha/9alpha10 heterpentamer. |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | synaptic currents that inhibit cochlear hair cells is blocked by alphaBtx and strychnine. alpha9 nACHR subunit is specifically expressed in cochlear hair cells and is specifically targeted by alphaBtx and strychnin in these cells (alpha7 and muscle-type nAChRs that are also sensitive to alphaBtx are not expressed). @ PMID:10875922 |
| SynGO annotation ID: | 1999 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |