| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-4. Gene symbol: CHRNA4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P09483 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA4 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | striatum, acetylcholinergic |
| Annotated paper: | Matsubayashi H, et al. "Postsynaptic alpha 4 beta 2 and alpha 7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons" Brain Res. 2004 Apr 16;1005(1-2):1-8 PMID:15044058 |
| Figure(s): | Fig.3, Fig.5, Table 1, Table 2 |
| Annotation description: | Spontaneous miniature fast postsynaptic currents (Fig.3, Table 1) and locally evoked EPSCs (Fig.5, Table 2) mediated by ACh (other transmitters and muscarinic ACh receptors were blocked) are mediated by alpha4beta2 and alpha7 nAChR subtypes. This is tested via sensivity for, respectively, DHβE and MLA. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1992 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |