| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-4. Gene symbol: CHRNA4. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P09483 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA4 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | basal ganglia, acetylcholinergic |
| Annotated paper: | Arroyo-Jim nez MM, et al. "Ultrastructural localization of the alpha4-subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra" J Neurosci. 1999 Aug 1;19(15):6475-87 PMID:10414976 |
| Figure(s): | Fig.8-11 |
| Annotation description: | Authors show "α4-subunit-like-immunoreactivity (LI)" in the postsynaptic specialization membrane of local cholinergic synapses in the substantia nigra with immunoperoxidase (Fig.8) and immunogold labeling (Fig.9). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Other report on localization of alpha 4 to 'integral component of postsynaptic specialization membrane (GO:0099060)' @ PMID:18403129 |
| SynGO annotation ID: | 1991 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |