| Annotated protein: | Neuronal acetylcholine receptor subunit alpha-3. Gene symbol: CHRNA3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R4G9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNA3 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | superior cervical ganglion (SCG), acetylcholinergic |
| Annotated paper: | Rassadi S, et al. "A null mutation for the alpha3 nicotinic acetylcholine (ACh) receptor gene abolishes fast synaptic activity in sympathetic ganglia and reveals that ACh output from developing preganglionic terminals is regulated in an activity-dependent retrograde manner" J Neurosci. 2005 Sep 14;25(37):8555-66 PMID:16162937 |
| Figure(s): | Fig.2 |
| Annotation description: | Background: this paper studies the cholinergic synapse located in the superior cervical ganglion (SCG). Fig.2: Without α3 expression, fast EPSPs are completely absent in sympathetic ganglia. This shows that the α3 subunit is part of the postsynaptic nACHR. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1988 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |