| Annotated protein: | Neuronal acetylcholine receptor subunit beta-4. Gene symbol: CHRNB4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R493 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHRNB4 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | spinal cord, acetylcholinergic |
| Annotated paper: | Lamotte d'Incamps B, et al. "Subunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors" Biochem Pharmacol. 2013 Oct 15;86(8):1114-21 PMID:23811311 |
| Figure(s): | Fig.1, 2 |
| Annotation description: | This paper investigates the motorneuron-Renshaw cell (MN-RC) synapse, a cholinergic synapse in the spinal cord. Fig.1+2: Sensitivity to DHβE of nicotinic EPSCs in Renshaw cells of various knockout mice are investigated. The most striking changes in DHβE-sensitivity were obtained for mice in which either the β2 or the β4 subunit had been deleted. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1984 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |