Annotated protein:Neuronal acetylcholine receptor subunit beta-2. Gene symbol: CHRNB2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9ERK7
antibody wiki:
SynGO gene info:SynGO data @ CHRNB2
Ontology domain:Biological Process
SynGO term:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)
Synapse type(s):spinal cord, acetylcholinergic
Annotated paper:Lamotte d'Incamps B, et al. "Subunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors" Biochem Pharmacol. 2013 Oct 15;86(8):1114-21 PMID:23811311
Figure(s):Fig.1, 2
Annotation description:This paper investigates the motorneuron-Renshaw cell (MN-RC) synapse, a cholinergic synapse in the spinal cord.

Fig.1+2: Sensitivity to DHβE of nicotinic EPSCs in Renshaw cells of various knockout mice are investigated. The most striking changes in DHβE-sensitivity were obtained for mice in which either the β2 or the β4 subunit had been deleted.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1983
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology