Annotated protein:Acetylcholine receptor subunit gamma. Gene symbol: CHRNG. Taxonomy: Bos taurus (Bovine). Uniprot ID: P13536
antibody wiki:
SynGO gene info:SynGO data @ CHRNG
Ontology domain:Biological Process
SynGO term:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)
Synapse type(s):Neuro-muscular junction
Annotated paper:Mishina M, et al. "Molecular distinction between fetal and adult forms of muscle acetylcholine receptor" Nature. 1986 May 22-28;321(6068):406-11 PMID:2423878
Figure(s):Table 1. Table 3.
Annotation description:Background: The nACHR epsilon subunit is expressed during fetal development and are replaced gradually by the nAChR gamma subunit. This paper proposes this idea for the first time.

Fig.1+2: nAChRs expressed in oocytes that contain the epsilon or the gamma subunit display difference (in combination with the alpha1, beta1 and delta subunits) in their gating properties.
Table 1: Comparison of single channel properties in fetal and adult muscle show differences in single channel properties that resemble properties of nAChRs that contain the epsilon or the gamma subunit expressed in oocytes.
Fig.4: The epsilon and gamma nACHR subunits are differentially expressed in a fetal to adult muscle tissue. This shows that there is a developmental switch from the epsilon to the gamma subunit containing receptor subtype. This observation matches the Ephys observations in oocytes and fetal/adult muscle tissue.
Evidence tracking, Biological System:Intact tissue
Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Whole-cell patch clamp
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:1981
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology