| Annotated protein: | Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]. Gene symbol: PLAT. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P19637 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PLAT |
| Ontology domain: | Cellular Component |
| SynGO term: | extrasynaptic space (GO:0099544) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lochner JE, et al. "Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging" J Neurobiol. 2006 May;66(6):564-77 PMID:16555239 |
| Figure(s): | Fig. 6 |
| Annotation description: | 25/11/2017 eg Evidence for activity-dependent release is provided by the study by Lochner et al. (2005) PMID 16555239. Accordingly the site of action is supposedly the synaptic cleft or the perisynaptic space |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Supplemental table S1 contains 492 proteins of the PSD fraction identified either by 2D gel electrophoresis followed by MS/MS or by LC-MS/MS. tPA was among these identified proteins. @ PMID:14720225 |
| SynGO annotation ID: | 1974 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |