| Annotated protein: | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1). Gene symbol: GRIN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35439 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIN1 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Barria A, et al. "Subunit-specific NMDA receptor trafficking to synapses" Neuron. 2002 Jul 18;35(2):345-53 PMID:12160751 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: Electrophysiological Tag of NMDA-R Allows Monitoring of Functional Insertion of Recombinant Receptor into Synapses. Note: The tagging technique uses over-expression of a mutant form of NR1 with slightly altered channel properties that allows detection of the participation of NMDA channels containing this subunit in synaptic transmission. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 1969 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |