| Annotated protein: | Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C). Gene symbol: CSPG5. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q71M36 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CSPG5 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle exocytosis (GO:2000300) |
| Synapse type(s): | midbrain, glutamatergic midbrain, GABAergic |
| Annotated paper: | Juttner R, et al. "Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity" Neuron. 2005 Apr 21;46(2):233-45 PMID:15848802 |
| Figure(s): | Fig. 5,6 |
| Annotation description: | CALEB-deficient mice display impaired synaptic function in juvenile but not adult synapses of the colliculus superior (Fig. 5). In particular, CALEB deficiency affect presynaptic properties at early developmental stages (Fig. 6). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1967 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |