| Annotated protein: | SPARC-like protein 1 (Matrix glycoprotein Sc1). Gene symbol: SPARCL1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P24054 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPARCL1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse organization (GO:0050807) |
| Synapse type(s): | midbrain, glutamatergic |
| Annotated paper: | Kucukdereli H, et al. "Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC" Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E440-9 PMID:21788491 |
| Figure(s): | Fig. 4C |
| Annotation description: | The synaptogenic activity of Hevin/SPARCL1 is antagonized by SPARC (Fig. 4C). Hevin is locally required for synapse formation (SynGO ID 1004) (Sing et al (2016), PMID: 26771491), at retinocollicular synapses. 20/11/2017 Pim - Note this protein is secreted from glial cells and is a regulator of synapse formation. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1966 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |