| Annotated protein: | Drebrin (Developmentally-regulated brain protein). Gene symbol: DBN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9QXS6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DBN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic membrane (GO:0045211) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Kobayashi C, et al. "Drebrin a content correlates with spine head size in the adult mouse cerebral cortex" J Comp Neurol. 2007 Aug 10;503(5):618-26 PMID:17559090 |
| Figure(s): | Fig 1 and 3 |
| Annotation description: | This paper shows the ultrastructural localization of drebrin A primarily in dendritic spines, as visualized by horseradish peroxidase/diaminobenzidine (HRP/DAB) staining (Figure 1). The localization was highest in the spine cytoplasm (~56%), with smaller fractions in or at the PSD (~25%), and at the plasma membrane (~15%) (Figure 3). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| Additional literature: | Drebrin A is localized at the plasma membrane of nascent spines. Drebrin A may be involved in organizing the dendritic pool of actin for the formation of spines and of axospinous excitatory synapses during early postnatal periods. @ PMID:15700273 |
| SynGO annotation ID: | 1965 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |