| Annotated protein: | Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Glutamate receptor beta-2) (GluR beta-2). Gene symbol: GRIK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P39087 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIK2 |
| Ontology domain: | Biological Process |
| SynGO term: | ligand-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Pinheiro PS, et al. "GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses" Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12181-6 PMID:17620617 |
| Figure(s): | Fig 1-4 |
| Annotation description: | Kainate receptor subunit Glur6 (=GRIK2) 22/11/2017 Pim Fig.1: "GluR7-Containing Presynaptic KARs Facilitate MF Short-Term Synaptic Plasticity" PPF is significantly reduced in GluR7-/- mice. PPF is a presynaptic phenomenon. Fig.2: "Long-Term Potentiation (LTP) Is Impaired in GluR7-/- Mice" Fig.3: "Subcellular localization and association of GluR6 and GluR7 subunits" Fig.4: "Properties of recombinant and native GluR7-containing KARs" - Based on integration of in vivo, PPI and heterologous expression data, the authors conclude that presynaptic modulation of SV release is mediated by GluR6/Glur7 heteromers. - The GluR6 KO animal has been demonstrated to display both pre and postsynaptic defects which overlaps with the conclusion of the primary paper of this ticket. |
| Evidence tracking, Biological System: | Intact tissue Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Western blot Biochemical fractionation (generic) |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | GluR6-/- mice display both pre- and postsynaptic phenotypes. The presynaptic role is detailed in the primary paper of this ticket (PMID:17620617) @ PMID:9580260 |
| SynGO annotation ID: | 1956 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |