| Annotated protein: | Ras-related protein Rab-4A (EC 3.6.5.2). Gene symbol: RAB4A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P05714 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAB4A |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of synaptic vesicle membrane (GO:0098993) |
| Synapse type(s): | cerebrum |
| Annotated paper: | Pavlos NJ, et al. "Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis" J Neurosci. 2010 Oct 6;30(40):13441-53 PMID:20926670 |
| Figure(s): | Table 1; Fig 2 |
| Annotation description: | Rab4A was detected by immunobloting on highly purified synaptic vesicles. The presence of Rab4A in synaptic vesicles was separately identified in another study (Takamori et al., 2006; PMID 17110340) by mass spectrometry. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| Additional literature: | Using mass spectrometry, Rab4A was found to be present on highly purified synaptic vesicles. @ PMID:17110340 |
| SynGO annotation ID: | 195 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |