| Annotated protein: | 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B). Gene symbol: HTR1B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P28564 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HTR1B |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle exocytosis (GO:2000300) |
| Synapse type(s): | Calyx of Held |
| Annotated paper: | Mizutani H, et al. "5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats" Eur J Neurosci. 2006 Oct;24(7):1946-54 PMID:17067296 |
| Figure(s): | Fig.2, 3 |
| Annotation description: | The authors used whole cell patch clamp recording from the calyx of held to show that application of 5HT attenuated EPSPs, and only agonists of 5HT1b receptor could mimick this effect (conversely for the respective antagonits). In addition, the authors found that 5HT affects the paired pulse ration thereby identifying its site of action as presynaptic. 19/3/2018 Pim - Fig.3: "5-Hydroxytryptamine (5-HT) inhibits presynaptic Ca2+currents, buthas no effect on presynaptic K+currents. " |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| SynGO annotation ID: | 1945 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |