| Annotated protein: | Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit). Gene symbol: GRID2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63226 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRID2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Matsuda K, et al. "Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions" Eur J Neurosci. 2011 Apr;33(8):1447-61 PMID:21410790 |
| Figure(s): | Fig. 7 |
| Annotation description: | Fig.7: "Cbln1 and Cbln2 serve as a presynaptic organizer in hippocampal neurons" "Immunocytochemical analyses showed that HEK293 cells expressing GluD2 but not those expressing GluD2ΔNTD accumulated synaptophysin-positive presynaptic terminals of hippocampal neurons only when recombinant HA-Cbln1 protein was added to the culture medium (Fig. 7A)." |
| Evidence tracking, Biological System: | Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1938 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |