| Annotated protein: | Cerebellin-1 (Brain protein D3) (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin (des-Ser1-cerebellin)]. Gene symbol: CBLN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9R171 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CBLN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynapse assembly (GO:1905606) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Matsuda K, et al. "Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer" Science. 2010 Apr 16;328(5976):363-8 PMID:20395510 |
| Figure(s): | Fig. 2, 3 |
| Annotation description: | Fig.2: "Cbln1 and the NTD of GluD2 cooperatively induce synaptogenesis in vitro and in vivo" Presynapse formation onto GluD2 expressing HEK cells is perturbed in Cbln1 KO neurons. Effect is absent when truncated versions of GluD2 are used. Synapse formation is restored in Cbln1 KO mice after injection of HA-Cbln1. Fig.3: "Cbln1 is a direct presynaptic organizer" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Whole-cell patch clamp |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1930 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |