| Annotated protein: | Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6). Gene symbol: ABHD6. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R2Y0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ABHD6 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | neocortex, glutamatergic neocortex, GABAergic |
| Annotated paper: | Marrs WR, et al. "The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors" Nat Neurosci. 2010 Aug;13(8):951-7 PMID:20657592 |
| Figure(s): | Fig.5 G-H |
| Annotation description: | ABHD6 localizes to postsynaptic spines of glutamatergic neurons in adult mouse prefrontal cortex (Figure 5G-H). Localization of ABHD6 is juxtaposed (not overlapping) with presynaptic CB1-receptors which bind 2-AG, the lipid metabolized by ABHD6. Supplementary Figure 9 shows ABHD6 is mainly expressed glutamatergic neurons and to a lesser extent GABAergic interneurons and some astrocytes. Postsynaptic membrane annotation: ABHD6 is an integral membrane protein (active site faces cytoplasm). 5/12/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
| Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| SynGO annotation ID: | 1929 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |