| Annotated protein: | Drebrin (Developmentally-regulated brain protein). Gene symbol: DBN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q07266 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DBN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic membrane (GO:0045211) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Aoki C, et al. "Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses" J Comp Neurol. 2005 Mar 21;483(4):383-402 PMID:15700273 |
| Figure(s): | Figs 10 and 11 |
| Annotation description: | Immuno-EM for drebrin A in neonatal tissue shows sub-membraneous labeling of drebrin A preferentially at developing, immature synaptic structures, more than at synaptic structures that have characteristics of more developed synapses. Based on these data it cannot be derived whether drebrin A is directly anchored in or to the membrane, more likely it is in close proximity, rather than directly attached. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 1926 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |