| Annotated protein: | Drebrin (Developmentally-regulated brain protein). Gene symbol: DBN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q07266 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DBN1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic actin cytoskeleton organization (GO:0098974) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Takahashi H, et al. "Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis" J Neurosci. 2003 Jul 23;23(16):6586-95 PMID:12878700 |
| Figure(s): | fig 1-8 |
| Annotation description: | this paper shows that downregulation of Drebrin A using antisense oligonucleotides reduces clustering of F-actin in dendritic spines and reduces the density of spines in hippocampal neurons, which could be restored by re-expression of Drebrin A. This suggests that Drebrin controls the organization of the actin cytoskeleton and thereby regulates spine morphogenesis |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 1924 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |