| Annotated protein: | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c). Gene symbol: ADAM10. Taxonomy: Mus musculus (Mouse). Uniprot ID: O35598 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADAM10 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Malinverno M, et al. "Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage" J Neurosci. 2010 Dec 1;30(48):16343-55 PMID:21123580 |
| Figure(s): | Fig.4, 5, 6, 8 |
| Annotation description: | Figure 4: "Role of ADAM10 synaptic localization on AMPA receptor composition" Figure 5: "Role of ADAM10 synaptic localization on AMPA receptor activity" Figure 6: "Inhibition of ADAM10 activity by TIMP-1 decreases ADAM10-mediated N-cadherin processing and induces a modification of AMPA receptors at synapses." Figure 8: "In vivo effect of ADAM10 synaptic activity on AMPA receptor composition and currents" 8/11/2017 Pim - Recap: ADAM10 cleaves N-cadherin (a homophilic interactin pre and postsynaptic adhesion molecule). Mislocalization of ADAM10 with a TAT-fused competing peptide or inhibition of ADAM10 activity with TIMP-1 results in spine morphology changes and different synaptic transmission (AMPAR composition, AMPA activity) in vitro and in vivo. I think that the role of N-cadherin in this story is illustrated in a correlational rather than a experimental fashion. No effect on cell adhesion is shown. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1923 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |