| Annotated protein: | Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1). Gene symbol: IL1RAPL1. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9NZN1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IL1RAPL1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Valnegri P, et al. "The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPdelta and RhoGAP2" Hum Mol Genet. 2011 Dec 15;20(24):4797-809 PMID:21926414 |
| Figure(s): | Fig.5, 6, 7 |
| Annotation description: | 17/11/2017 Pim Fig.5: "RhoGAP2 increases the number of synapses and the accumulation of endogenous synaptic proteins." Fig.6: "The IL1RAPL1/PTPδ complex recruits RhoGAP2 to synapses." Fig.7: "Dendritic spine number and morphology of hippocampal neurons are regulated by RhoGAP2." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 1920 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |