| Annotated protein: | Potassium voltage-gated channel subfamily A member 2 (RAK) (RBK2) (RCK5) (Voltage-gated potassium channel subunit Kv1.2). Gene symbol: KCNA2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P63142 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNA2 |
| Ontology domain: | Biological Process |
| SynGO term: | voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030) |
| Synapse type(s): | brainstem, glutamatergic Calyx of Held |
| Annotated paper: | Dodson PD, et al. "Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion" J Physiol. 2003 Jul 1;550(Pt 1):27-33 PMID:12777451 |
| Figure(s): | Figure 1 |
| Annotation description: | Voltage clamp experiments in the Calyx of Held using the specific blocker for Kv1.2 TsTX-Kalpha. Note that in this study the Kv1.2 channels are presynaptically very close to but not in the Calyx terminal. rule: NAS_MFCC-BP rationale: Protein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term 'voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)' is trivial and non-controversial. Pinf_CC: [P63142] SyNGO ID 183 (PMID:14614103, confocal) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 192 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |