Annotated protein:Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22). Gene symbol: ARHGAP22. Taxonomy: Homo sapiens (Human). Uniprot ID: Q7Z5H3
antibody wiki:
SynGO gene info:SynGO data @ ARHGAP22
Ontology domain:Biological Process
SynGO term:regulation of postsynapse organization (GO:0099175)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Valnegri P, et al. "The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPdelta and RhoGAP2" Hum Mol Genet. 2011 Dec 15;20(24):4797-809 PMID:21926414
Figure(s):Fig.5, 6, 7
Annotation description:17/11/2017 Pim
Fig.5: "RhoGAP2 increases the number of synapses and the accumulation of endogenous synaptic proteins."
Fig.6: "The IL1RAPL1/PTPδ complex recruits RhoGAP2 to synapses."
Fig.7: "Dendritic spine number and morphology of hippocampal neurons are regulated by RhoGAP2."
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Chiara Verpelli (ORCID:0000-0003-2949-9725)
Carlo Sala (ORCID:0000-0003-0662-9523)
Lab:CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy
SynGO annotation ID:1919
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology