Annotated protein:Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1). Gene symbol: MTOR. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P42346
antibody wiki:
SynGO gene info:SynGO data @ MTOR
Ontology domain:Cellular Component
SynGO term:postsynaptic cytosol (GO:0099524)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Tang SJ, et al. "A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus" Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72 PMID:11756682
Figure(s):fig 3
Annotation description:The figure shows the synaptic co-localization of mTOR with synapse in hippocampal neurons (P2; 14 DIV), furthermore mTOR colocalize with PSD-95, postsynaptic marker.

24/9/2017 Pim
- Literal: "The mTOR-positive regions were observed in the dendritic shaft in a diffuse pattern that extended into synaptic regions (Fig. (Fig.33Al). Consistent with the notion of postsynaptic localization of these proteins, double labeling with PSD-95 showed the signals from eIF-4E, 4E-BP1, and mTOR at synaptic regions almost completely overlapped with PSD-95 signals."
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491)
Vittoria Mariano (ORCID:0000-0002-9848-0262)
Achsel Tilmann (ORCID:0000-0002-1190-4481)
Claudia Bagni (ORCID:0000-0002-4419-210X)
Lab:Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
Additional literature:eIF4E-BP1 is detected in the growth cones of retinal explants by immunofluorescence microscopy (Fig 3B), i.e., the protein can also be axonal. @ PMID:25886013

eIF4E-BP1 is deteced in sciatic nerve preparations by immunofluorescence microscopy (Fig 9), i.e., the protein can also be axonal. @ PMID:26180210
SynGO annotation ID:1917
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology