| Annotated protein: | Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1). Gene symbol: SLC6A1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P23978 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC6A1 |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter reuptake (GO:0098810) |
| Annotated paper: | Guastella J, et al. "Cloning and expression of a rat brain GABA transporter" Science. 1990 Sep 14;249(4974):1303-6 PMID:1975955 |
| Figure(s): | Fig. 1 |
| Annotation description: | The paper describes cloning and functional expression of high-affinity GABA uptake system GAT-1. rule: NAS_MFCC-BP rationale: Protein has 'gamma-aminobutyric acid:sodium symporter activity (GO:0005332)' and is localized in the presynaptic membrane (show with high-resolution technique). The inference to term 'neurotransmitter reuptake (GO:0098810)' is trivial and non-controversial. Pinf_CC: [P23978] SynGO ID 86 (PMID:25120439, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Transmembrane transport assay |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 1912 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |