| Annotated protein: | Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11). Gene symbol: SLC6A11. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P31647 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC6A11 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | cerebral cortex, GABAergic |
| Annotated paper: | Melone M, et al. "Plasma membrane transporters GAT-1 and GAT-3 contribute to heterogeneity of GABAergic synapses in neocortex" Front Neuroanat. 2014 Jul 25;8:72 PMID:25120439 |
| Figure(s): | Fig.1 D-F, K-M |
| Annotation description: | Immunogold localization of GAT3 in presynaptic terminals and primarly in perisynaptic astrocytic processes (PAPs). Heterogeneous distribution of GATs at cortical symmetric synapses (layer II/III of the first somatic sensory cortex) (fig. 1). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | The localization of GAT-1 and GAT-3 was revealed on EM sections using DAB method. @ PMID:8731228 |
| SynGO annotation ID: | 1911 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |